As an attempt to minimize the environmental damage, the number of counterfeit medications, the potential hazard to human health, this study presents a framework for managing end-of-life pharmaceutical products. Establishing such an infrastructure capable of conducting proper EOL processing options would have numerous advantages when the environment, public health, and financial benefits are considered. Furthermore, a framework that includes environmental, economical and physical concerns for the reverse logistics operations of pharmaceutical products is proposed. Required Information Technology (IT) infrastructure is also provided.