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Targeting Tumors Using Invasive Assays Through Magnetosprillium Magneticum

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dc.contributor.author Divecha, Heena
dc.contributor.author Hajra, Mamta
dc.contributor.author Macwan, Isaac
dc.date.accessioned 2019-04-22T15:26:06Z
dc.date.available 2019-04-22T15:26:06Z
dc.date.issued 2019-03-29
dc.identifier.uri https://scholarworks.bridgeport.edu/xmlui/handle/123456789/4113
dc.description.abstract Magnetospirillum magneticum (AMB-1) are a species of magnetotactic bacteria that are capable of orienting along the earth’s magnetic field lines through their organelles called magnetosomes. Many studies have shown that certain engineered-bacteria can infect the tumor cells resulting in a controlled death of a tumor. This work deals with a technique utilizing AMB-1 along a predefined path through magnetotaxis, which can pave a way for selective doping as well as isolation of the tumor cells from a group of healthy cells through a magnetic invasive assay (MIA). For such a control, tiny mesh of vertical electrical coils each having a diameter of ~ 5 mm is fabricated, which establishes the path for the bacteria to move along the magnetic field lines. The molecular dynamics simulations at the interface of the bacterial cell surface proteins (MSP-1 & flagellin) and Chinese Hamster Ovary (CHO) cell surface containing cytoplasmic and extracellular proteins (BSG, B2M, SDC1, AIMP1, and FOS) will establish an association between the invading AMB-1 and the host CHO cells. The experimental demonstration involves the CHO invasion by the AMB-1 and isolation of selected CHO cells. Statistical analysis along with the relevant electron and force microscopy data will confirm the number of AMB-1 and CHO cells involved before and after invasion and the role of directional control. en_US
dc.language.iso en_US en_US
dc.subject Magnetospirillum magneticum en_US
dc.subject Tumor treatment en_US
dc.title Targeting Tumors Using Invasive Assays Through Magnetosprillium Magneticum en_US
dc.type Other en_US
dc.institute.department School of Engineering en_US
dc.institute.name University of Bridgeport en_US
dc.event.location Bridgeport, CT en_US
dc.event.name Faculty Research Day en_US

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