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Interaction of Chromium with Nickel in the Induction of Sister Chromatid Exchanges, in Chinese Hamster Ovary Cells

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dc.contributor.author Jin, Dugho en_US
dc.contributor.author Mallory, Stephanie en_US
dc.contributor.author Otfinoski, Jamie en_US
dc.contributor.author Charmoz, Alex en_US
dc.contributor.author Katsifis, Spiros en_US
dc.date.accessioned 2014-07-16T16:05:17Z
dc.date.available 2014-07-16T16:05:17Z
dc.date.issued 2011 en_US
dc.identifier.citation Poster 5 en_US
dc.identifier.other e5ab5fd5-06e5-db96-b243-8addaaf95c49 en_US
dc.identifier.uri https://scholarworks.bridgeport.edu/xmlui/handle/123456789/334
dc.description Epidemiological studies report that populations exposed to complex mixtures show increased incidence rates of cancer. Therefore, chemical interaction is of major concern in the assessment of risk by regulatory agencies. In this study, treatment of CHO (Chinese Hamster Ovary) cells with nickel chloride (in 1.0 and 5.0 uM), or sodium chromate (0.5, 1.0, and 2.5 uM) induce sister chromatid exchanges (SCE) in a dose dependent fashion. Statistical analysis of the interaction factor, show that the combined treatments of nickel ( 1.0 and 0.5 uM) with chromium (0.5, 1.0 and 2.5 uM) interacted antagonistically for the induction of SCE. Previously, we reported that nickel with chromium, with UV light and with X-rays interacted antagonistically for the induction of SCE and MN (micronuclei) in human peripheral lymphocytes. These observations indicate that heavy metals, such as nickel and chromium, present in complex mixtures, may reduce the response, even in the presence of strong SCE or MN inducers, and may lead, therefore, to an underestimate of chemical exposure as assessed by these assays. Therefore, further studies are a necessity. en_US
dc.subject Faculty research day en_US
dc.title Interaction of Chromium with Nickel in the Induction of Sister Chromatid Exchanges, in Chinese Hamster Ovary Cells en_US
dc.type Presentation en_US
dc.notes Undergraduate Student First (1st) Place en_US
dc.institute.department School of Arts and Sciences en_US
dc.institute.name University of Bridgeport en_US
dc.event.name Faculty Research Day en_US

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