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Understanding the Molecular and Structural Selectivity of Oxidant-induced Nitration and its Reversal in Sarcoplasmic Reticulum Ca2+ -ATPase SERCA2a vs. SERCA1a

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dc.contributor.author Kratzer, Marla
dc.contributor.author Macwan, Isaac
dc.contributor.author Heerdt, Paul M.
dc.contributor.author Deeb, Ruba S.
dc.date.accessioned 2018-04-13T14:00:56Z
dc.date.available 2018-04-13T14:00:56Z
dc.date.issued 2018-03-23
dc.identifier.uri https://scholarworks.bridgeport.edu/xmlui/handle/123456789/2174
dc.description.abstract The present study uses existing sequence (SERCA1a & SERCA2a) and structure (SERCA1a) information to extrapolate a tertiary structure construct for SERCA2a using computational modeling software. A comparison of SERCA1a and SERCA2a models could reveal structural anomalies that explain the basis for selective and specific Tyr nitration in SERCA2a but not SERCA1a. en_US
dc.language.iso en_US en_US
dc.subject Molecular selectivity en_US
dc.subject Oxidant-induced nitration en_US
dc.subject Sarcoplasmic Reticulum Ca2+ -ATPase en_US
dc.subject Structural selectivity en_US
dc.title Understanding the Molecular and Structural Selectivity of Oxidant-induced Nitration and its Reversal in Sarcoplasmic Reticulum Ca2+ -ATPase SERCA2a vs. SERCA1a en_US
dc.type Other en_US
dc.institute.department School of Engineering en_US
dc.institute.name University of Bridgeport en_US
dc.event.location Bridgeport, CT en_US
dc.event.name Faculty Research Day en_US


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