Osteoarthritis (OA) appears to be one for the unfortunate consequences of evolution of bony skeleton. Despite much study in other areas, the impact of diet in terms of caloric balance and the biochemical effects of essential nutrients is only just being explored.There is little question that proper weight control will positively influence the course of Osteoarthritis of some joints. when it comes to the role of non-caloric essential nutrients the impact is less clear.A number of studies have shown that a large percentage of patients with OA are ingesting less than the USRDA for vitamins A, C, D, E pysidoxien, folacin, pantothenic acid and the minerals zinc, magnesium, iron, and calcium. Many substance such as vitamins A, C, E, niacin and sulfur have shown promising results in intial studies with Osteoarthritis. However much, much more work remains to be done and until these studies are performed any clinical recommendations in megadose ranges for vitamins and mineral supplementation by OA patients should remain guarded.