Abstract:
The purpose of this review is to assess the evidence for whether IL-6 elevation is present in autism, particularly within the CNS, and to evaluate the neuroanatomical and behavioral implications of elevated IL-6, and more broadly, neuroinflammation. Maternal immune activation is explored as a plausible pathogenetic mechanism for IL-6 elevation as well as the presence of autistic behaviors. The effects of IL-6 on gene expression are investigated in relation to the JAK-STAT pathway.
Description:
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