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Amyloid Precursor Protein Processing in Autism and Alzheimer’s Disease and the Potential Therapeutic Use of Trehalose

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dc.contributor.author Sanders, Kimberly M.
dc.date.accessioned 2016-01-25T16:06:49Z
dc.date.available 2016-01-25T16:06:49Z
dc.date.issued 2013
dc.identifier.citation K.M. Sanders, "Amyloid Precursor Protein Processing in Autism and Alzheimer’s Disease and the Potential Therapeutic Use of Trehalose", ND dissertation, College of Naturopathic Medicine, Univ. of Bridgeport, Bridgeport, CT, 2013. en_US
dc.identifier.uri https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1396
dc.description This thesis is being archived as a Digitized Shelf Copy for campus access to current students and staff only. We currently cannot provide this open access without the author's permission. If you are the author of this work and desire to provide it open access or wish access removed, please contact the Wahlstrom Library to discuss permission. en_US
dc.description.abstract Multiple neurodegenerative diseases, including Alzheimer’s disease and autism, are associated with the presence of amyloid material in the brain which has been shown to lead to impaired synaptic transmission and neurotoxicity (1). However, children with autism are found to have excessive amyloid generated through a different pathway than those with Alzheimer’s disease (1). The type of amyloid present in the brains of children with autism is linked with brain overgrowth and impaired synaptic connections, but controversy exists about whether this material actually forms amyloid plaques in children (1). However, most research suggests that the early accumulation of amyloid material in childhood may eventually lead to amyloid plaque formation in adult autistics. One novel treatment for reducing such amyloid plaque formation is the disaccharide trehalose, which has been shown to enhance destruction of amyloid plaques and reduce neurotoxicity (2). Trehalose may prove to be safe and effective for both the treatment of prevention of amyloid plaques in children with autism. en_US
dc.language.iso en_US en_US
dc.subject Naturopathy en_US
dc.subject Autism en_US
dc.subject Alzheimer’s disease en_US
dc.subject Amyloid precursor protein en_US
dc.subject Amyloid beta en_US
dc.subject Amyloid plaques en_US
dc.subject Trehalose en_US
dc.subject Autophagy en_US
dc.subject Mechanistic target of rapamycin (mTOR) en_US
dc.title Amyloid Precursor Protein Processing in Autism and Alzheimer’s Disease and the Potential Therapeutic Use of Trehalose en_US
dc.type Thesis en_US
dc.institute.department College of Naturopathic Medicine en_US
dc.institute.name University of Bridgeport en_US


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