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Epigenetcs and Naturopathic Medicine: Their Role in Prostate Cancer

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dc.contributor.author Cano, Julian
dc.date.accessioned 2016-01-21T16:54:42Z
dc.date.available 2016-01-21T16:54:42Z
dc.date.issued 2013
dc.identifier.citation J. Cano, "Epigenetcs and Naturopathic Medicine: Their Role in Prostate Cancer", ND dissertation, College of Naturopathic Medicine, Univ. of Bridgeport, Bridgeport, CT, 2013. en_US
dc.identifier.uri https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1394
dc.description This thesis is being archived as a Digitized Shelf Copy for campus access to current students and staff only. We currently cannot provide this open access without the author's permission. If you are the author of this work and desire to provide it open access or wish access removed, please contact the Wahlstrom Library to discuss permission. en_US
dc.description.abstract For the past decade, Prostate specific antigen levels have been the diagnostic method to diagnose Prostate cancer. Testing PSA gene levels by themselves are not enough to diagnose prostate cancer. In fact, one can argue that DNA hypermethylation, histones methylation and hypoacetylation genes are better markers to diagnose prostate cancer. These markers are the most common somatic alterations present in prostate cancer. Furthermore, evidence suggests that epigenetic mechanisms, such as DNA hypermethylation, histones methylation and hypoacetylation affect gene expression in patients with prostate cancer. One can argue that one of the first hallmarks of epigenetic alterations in DNA hypermethylation is the addition of a methyl group to the 5’-carbon of cytosine in the Cytosine-phosphate-Guanine (CpG) sequences catalyzed by DNA methyltransferase. Furthermore, such epigenetics aberration modified the humoral response, cell cycle control, tumor invasion/tumor architecture, DNA damage repair, signal transduction and inflammation response genes. The objective of Naturopathic medicine is to identify and prevent the Epigenetics aberrations in DNA and histones genes in the genome sequence. Furthermore, a potential treatment can be a combination of DNA methyltransferase and Histones deacetylation inhibitors for patients with prostate cancer by using nutrition and botanical medicine. en_US
dc.language.iso en_US en_US
dc.subject Epigenetics en_US
dc.subject Deoxyribonucleic acid (DNA) hypermethylation en_US
dc.subject Histones methylation en_US
dc.subject Histones acetylation en_US
dc.subject Prostate cancer en_US
dc.subject Polyphenols en_US
dc.subject Naturopathy en_US
dc.subject Deoxyribonucleic acid (DNA) en_US
dc.title Epigenetcs and Naturopathic Medicine: Their Role in Prostate Cancer en_US
dc.type Thesis en_US
dc.institute.department College of Naturopathic Medicine en_US
dc.institute.name University of Bridgeport en_US


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