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Comparative Study on Natural and Synthetic 5alpha Reductase Inhibitors-Treating Male Pattern Baldness Using ADMET Predictor

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dc.contributor.author Kalige, Uday Kirthi
dc.date.accessioned 2015-10-02T18:29:53Z
dc.date.available 2015-10-02T18:29:53Z
dc.date.issued 2014-12
dc.identifier.citation U.K. Kalige, "Comparative Study on Natural and Synthetic 5alpha Reductase Inhibitors-Treating Male Pattern Baldness Using ADMET Predictor", M.S. dissertation, Dept. of Biomedical Engineering, Univ. of Bridgeport, Bridgeport, CT, 2014. en_US
dc.identifier.uri https://scholarworks.bridgeport.edu/xmlui/handle/123456789/1330
dc.description The author desires this thesis not to be shared open access and is only available to current students and staff. en_US
dc.description.abstract The main objective of this paper is to compare the Natural 5 alpha Reductase inhibitors with the Synesthetic drugs like Minoxidil and Finasteride, which are used in treating Male Pattern Baldness [MPB]. This is a hair loss disorder which leads to baldness. When the androgen like testosterone in the body start to circulate after puberty, the presence of the enzyme 5 alpha Reductase initiates the conversion of Testosterone to Dihydrotestostron [DHT][ 1]. DHT is site specific and has high affinity for androgen receptors especially, to the once found near to the hair follicles. Using the advanced software version ADMET Predictor 6.2 developed by Simulation plus-Inc. a drug comparison is carried out between Minoxidil, Finasteride and the chemical constituents found in Saw palmetto berries-Beta Sitosterol taking the referral drugs as testosterone and DHT. en_US
dc.language.iso en_US en_US
dc.subject Dihydrotestostron en_US
dc.subject Minoxidil en_US
dc.subject Finasteride en_US
dc.subject Testosterone en_US
dc.subject Male pattern baldness en_US
dc.title Comparative Study on Natural and Synthetic 5alpha Reductase Inhibitors-Treating Male Pattern Baldness Using ADMET Predictor en_US
dc.type Thesis en_US
dc.institute.department School of Engineering en_US
dc.institute.name University of Bridgeport en_US


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