Abstract:
This study focuses on biomarkers and related factors associated directly or indirectly with Alzheimer’s disease. Fluid biomarkers, inflammatory biomarkers and various imaging technologies are considered. Amyloid βeta protein and tau protein are the two major factors linked either causally or diagnostically with Alzheimer’s. Concentrations of these two proteins in blood and cerebrospinal fluid are evaluated for correlations to Alzheimer’s disease onset and progression and are being studied to determine whether they act independently or interact in some manner. Amyloid βeta detected in plasma shows little or no correlation with Alzheimer’s progression, whereas, tau protein detected in cerebrospinal fluid correlates with Alzheimer’s disease. Current literature has been reviewed for the detection, characterization and correlation of various biomarkers with Alzheimer’s disease.
