The Effect of Steviol and Hyperthermia on Murine Mammary Adenocarcinoma Cells

Abstract

Steviol has been reported to mediate G2/M phase arrest in response to DNA damage thus preventing entry into the M phase. At that point, further treatment with hyperthermia might induce a total apoptosis. Thus, in this experiment, Chinese hamster ovary (CHO) and MTGB (a murine mammary adenocarcinoma) cells will be treated with steviol alone, steviol with hyperthermia, and hyperthermia alone to evaluate their cytotoxic and apoptotic potential. Their cytotoxicity will be compared to determine if hyperthermia could work with steviol to increase its cytotoxicity and apoptotic effect.