An olfactory subsystem that detects carbon disulfide and mediates food-related social learning
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Authors
Kelliher, Kevin R.
McDougall, L.M.
Leinders-Zufall, T.
Zufall, F.
Munger, S.D.
Issue Date
2012
Type
Presentation
Language
Keywords
Faculty research day
Alternative Title
Abstract
In mammals, pheromones and other social cues can promote mating or aggression behaviors; can communicate information about social hierarchies, genetic identity and health status; and can contribute to associative learning. However, the molecular, cellular, and neural mechanisms underlying many olfactory-mediated social interactions remain poorly understood. Here, we show a specialized olfactory subsystem that includes olfactory sensory neurons (OSNs) expressing the receptor guanylyl cyclase GC-D, the cyclic nucleotide-gated channel subunit CNGA3, and the carbonic anhydrase isoform CAII (GC-D(+) OSNs) is required for the acquisition of socially transmitted food preferences (STFPs) in mice.
Description
Citation
Poster 92