Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training
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Authors
Ash, Garrett I.
Kostek, Matthew A.
Lee, Harold
Angelopoulos, Theodore J.
Clarkson, Priscilla M.
Gordon, Paul M.
Moyna, Niall M.
Visich, Paul S.
Zoeller, Robert F.
Price, Thomas B.
Issue Date
2016-01-28
Type
Article
Language
en_US
Keywords
Strength training , Cortisol , Variant genotypes , Muscle analysis , Magnetic resonance imaging , Muscle proteins , Alleles , Physical activity
Alternative Title
Abstract
Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm2) pre- and post-resistance training. Subjects were genotyped for NR3C1 -2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes. We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol’s actions in muscle tissue as they interact with sex differences in cortisol production.
Description
Citation
Ash GI, Kostek MA, Lee H, Angelopoulos TJ, Clarkson PM, et al. (2016) Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training. PLOS ONE 11(1): e0148112. https://doi.org/10.1371/journal.pone.0148112
Publisher
PLOS