Understanding the Molecular and Structural Selectivity of Oxidant-induced Nitration and its Reversal in Sarcoplasmic Reticulum Ca2+ -ATPase SERCA2a vs. SERCA1a
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Authors
Kratzer, Marla
Macwan, Isaac
Heerdt, Paul M.
Deeb, Ruba S.
Issue Date
2018-03-23
Type
Other
Language
en_US
Keywords
Molecular selectivity , Oxidant-induced nitration , Sarcoplasmic Reticulum Ca2+ -ATPase , Structural selectivity
Alternative Title
Abstract
The present study uses existing sequence (SERCA1a & SERCA2a) and structure (SERCA1a) information to extrapolate a tertiary structure construct for SERCA2a using computational modeling software. A comparison of SERCA1a and SERCA2a models could reveal structural anomalies that explain the basis for selective and specific Tyr nitration in SERCA2a but not SERCA1a.