Prep Adherence to Tenofovir-Based Therapeutics Seems Efficacious in Reducing HIV Infection Dissemination: A Comparative Evaluation on The Therapeutic Potency of Tenofovir-Based Prep & Dapivirine-Based Antiretroviral (ARV) Microbicide in HIV Prevention
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Authors
Paria, Ananya
Issue Date
2019-08-25
Type
Thesis
Language
en_US
Keywords
Human immunodeficiency virus (HIV) prevention , Pre-exposure prophylaxis , High-risk populations
Alternative Title
Abstract
HIV/AIDS is a serious public health issue causing millions of morbidities and thousands of mortalities with the immense socio-economic burden. This disease adversely impacts population science on a global scale. The development of an effective HIV vaccine remains a therapeutic challenge. Two principles pre-exposure prophylaxis (PrEP) approaches using Tenofovir-based, and Dapivirine-based therapeutic regimens are compared to HIV preventive efficacy in high-risk populations. This dissertation aims to determine if PrEP adherence to Tenofovir-based therapeutics as single or combined treatment approaches are more efficacious than Dapivirine microbicides-based therapeutic approaches in HIV prevention in high-risk populations. The trial outcomes are methodically segmented in four different therapeutic clusters of i) TDF-FTC, ii) TDF-alone, iii) 1% TFV gel, and iv) DVR to determine HIV preventive efficacy from individual treatment cluster, targeting 26,755 HIV uninfected high-risk populations. The cumulative HIV preventive therapeutic potency is assessed on a PICO table and measured conducting box plot and waterfall analyses. The results of this analysis demonstrated a 55% risk reduction from TDF-FTC combined treatment, 34% from TDF single treatment, 27% from TFV single treatment and 42% risk reduction from DVR Microbicides ring single treatment clusters. Men achieved the highest HIV preventive efficacy at 86% from the TDF-FTC group, whereas women achieved 71% of HIV preventive efficacy from the TDF-alone group.
Description
This dissertation is being archived for campus access to current students and staff only at the request of the author.
Citation
A. Paria, "Prep Adherence to Tenofovir-Based Therapeutics Seems Efficacious in Reducing HIV Infection Dissemination: A Comparative Evaluation on The Therapeutic Potency of Tenofovir-Based Prep & Dapivirine-Based Antiretroviral (ARV) Microbicide in HIV Prevention", Ph.D. dissertation, School of Health Science, Univ. of Bridgeport, Bridgeport, CT, 2019.
Publisher
University of Bridgeport