Resistin Accelerates Cardiac Fibroblast Differentiation into Myofibroblasts and Causes Heart Fibrosis
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Authors
Singh, Rajvir
Kaundal, Ravinder K.
Bouchareb, Rihab
Lebeche, Djamel
Issue Date
2025-04-04
Type
Other
Language
en_US
Keywords
Cardiac Fibrosis , Resistin , Myofibroblast Differentiation
Alternative Title
Abstract
Cardiac fibrosis (CF) is a major cause of heart failure in patients with ischemic injury, obesity, and diabetes. CF is characterized by excessive deposition of extracellular matrix (ECM) proteins and myofibroblast differentiation, leading to profound changes in ventricular architecture and geometry that ultimately reduce cardiac function. Various cell types, including fibroblasts and myofibroblasts, are responsible for ECM protein synthesis. Resistin, an adipokine, has been associated with obesity, insulin resistance, and diabetes. Previous findings have implicated resistin in the development of cardiac fibrosis; however, the molecular mechanisms underlying this process remain unclear. In this study, we investigated whether resistin regulates the transdifferentiation of fibroblasts into myofibroblasts and examined the molecular pathways responsible for the resistin-induced fibrotic response.
Description
UB Rise 2025
Department of Chemistry
College of Science and Society