Effects of DIO2 Thr92Ala SNP on Thyroid Hormonogenesis: A Narrative Review of the Literature
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Authors
Maher, Kathleen B.
Issue Date
2021-01-09
Type
Other
Language
en_US
Keywords
DIO2 Thr92Ala , Thyroid hormonogenesis
Alternative Title
Abstract
Background: Individual genetic differences affecting thyroid hormone production may lead to treatment resistance in hypothyroid patients. Identification of these differences may lead to better treatments. Objective: To review the current literature examining the effect of the Thr92Ala DIO2 polymorphism on thyroid hormonogenesis. Methods: Literature search of scholarly databases for primary human studies investigating the impact of the DIO2 Thr92Ala polymorphism on hypothyroidism was performed. Results and Conclusion: The Thr92Ala SNP of the DIO2 gene has been shown to negatively impact the conversion of inactive T4 to the active T3. Hypothyroid carriers of this SNP treated solely with levothyroxine (LT4) may have suboptimal T3 levels leading to poorer outcomes.