A Computational Approach Using Cellular Potts Model for Simulation of Neural Stem Cells Grown in PCL-Graphene Scaffolds
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Authors
Haliti, Pegi
Issue Date
2018-03-23
Type
Other
Language
en_US
Keywords
Cellular Potts model , Polycaprolatone (PCL)-graphene nanostructured scaffolds , Stem cells
Alternative Title
Abstract
In the last decade, new computational model environment that includes both discrete and continuous models is getting more attention. One of the most well-known hybrid approaches is Cellular Potts Model also known as the Glazier-Graner-Hogeweg model, a lattice-based, cellular level computational framework that accurately describes biological phenomena including stem cell differentiation, tumor growth, cell migration, angiogenesis, cell rearrangement and adhesion. In this study we use the Cellular Potts Model (CPM) to design a dynamic microenvironment for cellular organization and its functioning at a Nano-scale level. Particularly we focus on cellular level interactions of neural stem cells grown on a Poly(ε-caprolactone) (PCL)-graphene scaffolds which are proven to provide better protein and cell adhesion and eventually increase the biological responses of the cells. The interactions such as cell-cell, cell-extracellular matrix adhesion and cellular motility contribute to the system’s energy given by a function known as Hamiltonian which manages the lattice rearrangement using the stochastic Monte Carlo’s model by minimizing the energy.