Susceptibilty of Leishmania promastigotes to Amphotercin B
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Authors
Almutiary, Maha
Ross, Anthony
Issue Date
2023-03-24
Type
Other
Language
en_US
Keywords
Infection , Anti-Leishmanial drugs , Health
Alternative Title
Abstract
Leishmaniasis is a protozoal infection causing significant morbidity and mortality worldwide, despite aggressive efforts to control the disease. Multiple pharmacologic agents have been shown to be effective in the treatment of this infection; these include pentavalent antimonials, various formulations of amphotericin B, miltefosine, paromomycin, pentamidine and sodium stibogluconate. (Burza et al., 2018). However, significant issues still exist with the clinical use of these drugs, including adverse effects, costs, and routes of administration and the increasing rate of drug resistance in many Leishmania species(Ghorbani 2018). In addition, one of the challenges in addressing the clinical treatment of the infection is that the considerable variation in susceptibility among some Leishmania species to the various drugs currently in use.
Description
UB RISE 2023, Dept. of Biology, School of Science and Society, University of Bridgeport.