Epigenetcs and Naturopathic Medicine: Their Role in Prostate Cancer
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Authors
Cano, Julian
Issue Date
2013
Type
Thesis
Language
en_US
Keywords
Epigenetics , Deoxyribonucleic acid (DNA) hypermethylation , Histones methylation , Histones acetylation , Prostate cancer , Polyphenols , Naturopathy , Deoxyribonucleic acid (DNA)
Alternative Title
Abstract
For the past decade, Prostate specific antigen levels have been the diagnostic method to diagnose Prostate cancer. Testing PSA gene levels by themselves are not enough to diagnose prostate cancer. In fact, one can argue that DNA hypermethylation, histones methylation and hypoacetylation genes are better markers to diagnose prostate cancer. These markers are the most common somatic alterations present in prostate cancer. Furthermore, evidence suggests that epigenetic mechanisms, such as DNA hypermethylation, histones methylation and hypoacetylation affect gene expression in patients with prostate cancer. One can argue that one of the first hallmarks of epigenetic alterations in DNA hypermethylation is the addition of a methyl group to the 5’-carbon of cytosine in the Cytosine-phosphate-Guanine (CpG) sequences catalyzed by DNA methyltransferase. Furthermore, such epigenetics aberration modified the humoral response, cell cycle control, tumor invasion/tumor architecture, DNA damage repair, signal transduction and inflammation response genes. The objective of Naturopathic medicine is to identify and prevent the Epigenetics aberrations in DNA and histones genes in the genome sequence. Furthermore, a potential treatment can be a combination of DNA methyltransferase and Histones deacetylation inhibitors for patients with prostate cancer by using nutrition and botanical medicine.
Description
This thesis is being archived as a Digitized Shelf Copy for campus access to current students and staff only. We currently cannot provide this open access without the author's permission. If you are the author of this work and desire to provide it open access or wish access removed, please contact the Wahlstrom Library to discuss permission.
Citation
J. Cano, "Epigenetcs and Naturopathic Medicine: Their Role in Prostate Cancer", ND dissertation, College of Naturopathic Medicine, Univ. of Bridgeport, Bridgeport, CT, 2013.