Pulmonary Surfactant Proteins: Function, Structure, and Structural Binding with Carbon Nano-tubes
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Authors
Anjum, Mohammed Naveed
Gondi, Dhanalakshmi
Dharmadhikari, Bhushan V.
Hmurcik, Lawrence V.
Patra, Prabir
Issue Date
2012
Type
Presentation
Language
Keywords
Faculty research day
Alternative Title
Abstract
Description
Alveolar air sacs of lungs are filled with pulmonary surfactant made up of mixture of phospholipids and proteins namely SP-A, SP-B,SP-C and SP-D secreted by Type-II alveolar cells. SP-A and SP-D are hydrophilic proteins and play role in pulmonary host defense mechanism. SP-B and SP-C are hydrophobic; determining the formation of surfactant layers and lowers the surface tension. Deficiency of the surfactant proteins is the leading cause of respiratory distress syndrome in premature newborns leading to breathing problems or even death. Early detection of this deficiency is very important; in this poster, we will discuss a design idea of a carbon nanotube based sensor to quantify the pulmonary surfactant protein.
Citation
Poster 47