Effects of Leukocyte-Platelet Rich Fibrin and Nanoporous Scaffolds on Cell Proliferation and Cell Migration

Abstract

In regenerative medicine, repair and regeneration of defects and damage in both soft and hard tissues still remain a challenge. Hence, better bioengineering strategies and biomaterials are needed. Autologous platelet concentrates are potential tools from which regenerative medicine can benefit. The Leukocyte Platelet Rich Fibrin (L-PRF) is a subfamily of the PRF concentrates that has been in the spotlight because of its simplicity. The presence in its enriched solid three-dimensional fibrin matrix of leukocytes, proteins, cytokines, growth factors, and stem cells give this biomaterial angiogenic, osteogenic, hemostatic, anti-inflammatory, antimicrobial, analgesic, and wound healing properties. Polymeric substances, such as PLGA have demonstrated potential to operate as a scaffold for bone volume augmentation. The ability to tailor the material's properties at the molecular level is one the benefits that allow these materials to be used as proper scaffolds for cells.